The accident happened on I-95 southbound near mile marker 217 in Howland.
According to State Police the driver, 30 year-old Leslie Greenlaw, drifted into the median after losing control of the vehicle.
As a result, the car went down into an embankment and rolled over.
Her passenger, 30 year-old Ted MacArthur of Fort Fairfield was not wearing a seatbelt and was ejected from the vehicle.
Police said as a result MacArthur was pronounced dead at the scene.
Greenlaw was transported to Northern Light Eastern Maine Medical Center where she is being treated for non-life threatening injures.
State troopers are continuing to investigate the cause of the crash.