Participants and supporters are expected to begin arriving at Bangor Waterfront around 7 a.m.
The 5K run is held each year to commemorate the life of Erin Wooley, a former intern who died in 2010.
This year, the proceeds from Erin's Run will benefit Partners for Peace, the Bangor Y and the University of Maine's swimming and diving team.
"And we're always really glad to be a part of this event because [Wooley] was so passionate about domestic violence survivors. That's why the color is purple, because purple is the color for domestic violence survivors," said Casey Faulkingham, community response team leader for Partners for Peace.
People who want to register for Erin's Run can do so online or at the waterfront before the event begins.