Fire officials said the call for a fire on Moore Street came in around 10:30 a.m. Sunday.
About eight departments responded to get the fire contained in a little over an hour but fire crews said the fire had gotten a head start on them.
The man's identity has not been released but officials said he was an adult. They believe he lived alone.
The home is a total loss.
No firefighters were hurt, according to Anson fire crews.
In the coming week, the Maine State Fire Marshal will be investigating a cause.