State Police say it happened around 5:00 p.m. on Route 117.
Authorities say a 24-year-old man was driving in his car when his vehicle crossed the center line and struck a pickup truck head-on.
The man was killed in the collision.
The driver of the truck, a 55-year-old woman, was taken to the hospital with non-life threatening injuries.
A public safety spokesperson says the names of the drivers will be released Thursday to allow family members to be notified.
The road was closed for more than five hours as first responders worked to clear the scene.