The Republican senator wrote on social media that she spoke to a waitress in Bangor, whose husband works for TSA.
The woman told Sen. Collins she had to get a loan to pay for her mortgage this month, something the senator says is "just wrong."
Sen. Collins went on to say: "I continue to believe that a compromise is possible because this is a problem that we have to solve."
Monday marks the 24th day of the partial government shutdown over border security.
It is now the longest shutdown in U.S. history.