The crash happened shortly before 7 p.m. at the entrance of the rest area at mile marker 178 on the southbound side of Interstate 95.
Officials said the vehicle went off the road and barrel rolled before coming to rest in the woods. One of the passengers was ejected from the vehicle while the other remained inside. Both were taken to the hospital with what police believed to be serious but not life-threatening injuries.
Fire departments from Hampden and Carmel assisted at the scene, according to Trooper Steve Morrell of the Maine State Police
"They're running a thermal scan around the woodline and the immediate area of the crash to ensure there were no other victims, or no other occupants, of the vehicle, just as a precaution," Morrell said.
About an hour after that crash, traffic had to be rerouted through the rest area when a second accident took place near the same area.
A passing motorist hit a piece of debris, setting off a chain-reaction crash involving three more vehicles. No one was injured in that accident.