It happened around 2:45 Wednesday afternoon.
Sheriff's deputies responded to Route 191 in Cathance Township for the reported crash.
Police say a school bus was traveling south when it was struck by a motorcycle traveling in the opposite direction that crossed the center line.
Authorities say the driver of the motorcycle, 34-year-old Nicholas Palladino of Baileyville, did not survive the accident.
The school bus was not carrying any children and the bus driver was taken to the hospital as a precaution.