The vintage aircraft is traveling from Maine to John F. Kennedy International Airport in New York, where it will be repurposed as a cocktail lounge.
The Lockheed Constellation is one of four still existing in the world.
It will stay at the TWA Hotel at JFK, where it will sit just feet from the airport terminals.
The plane will be able to seat more than 100 people and will be themed to the 1960s.
The total cost for the project, including a renovated hotel, is $265 million.
Those involved with the driving this massive plane down Interstate 95 south said it will not be an easy feat.
"Our convoy is over a mile long," TWA Hotel CEO Tyler Morse said.
"We had the state police, oversized load, and then our lodge here is 150 feet long. This is quite a movement all the way down the northeast corridor," he said.
The Constellation airplane, which doesn't fly anymore, left Tuesday morning from Auburn-Lewiston Airport. Its trip to New York will take several days because it will be traveling at about 15 miles per hour.
The hotel is set to open in 2019.