Crews from Monroe and several nearby towns were called to Dickey Hill Road shortly after 1 p.m., when a passerby saw that the house was on fire and called for help.
When the first firefighters arrived, flames were already shooting through the roof.
Officials say a tanker truck from West Frankfort rolled over while on its way to the scene.
"When he came around the corner, the sun was shining right in his eyes," West Frankfort Fire Chief Roy Stone said of the tanker truck's driver.
"He got off over the edge of the tar with his tire and that dragged him right out into the ditch and as he got back into the road, he overcorrected and flipped right over," Stone said.
Authorities said that the owners of the home were in Belfast when the fire started.
The state fire marshal's office has been called in to try to determine a cause.
The driver of the fire truck was the only person aboard when the truck rolled over. Officials say he was checked by an ambulance crew but did not go to the hospital.
West Frankfort's chief said the department does have a second truck to cover the area until they can replace the one destroyed.