MDEA agents began to investigate reports of drug activity by 27-year-old Jared Fogg and 29-year-old Rogelio Rios of Florida earlier in the week.
Officials said agents found the pair and put them under surveillance. The investigation culminated with the search of Rios vehicle and the motel room which netted the seizure of 125 grams of crystal methamphetamine, 42 grams of heroin and more than $19,000 in cash.
Two 9mm handguns were also seized, police said one of which was found to have been stolen.
Fogg and Rios, who are both charged with multiple counts of aggravated trafficking, were taken to the Penobscot County jail. Their bail is set at $75,000.