The shots were fired just before 11 p.m. on Friday near 158 Spring St.
Several officers converged on the area and formed a safety perimeter to contain any potential threats.
Police said nobody was found to have been injured or struck by the gunfire.
Spring Street was closed to all traffic between Holland Street and Riverside Street for several hours as detectives and officers investigated and searched for evidence.
Anyone with information about the incident is asked to call Detective Rose at 513-3001.