Fire officials on scene said the family of five got out in time, but the house is a total loss.
They said they were worried about the remaining structure, so a demolition team was knocked down what was left of the home. This was also so firefighters could put out hot spots.
A dozen different fire departments responded to put out the fire.
Thorndike Fire Chief Seth Curra said the family lost a couple pets.
"The family got out safely fortunately, but unfortunately they lost two cats," said Chief Curra. "I know the family personally, they're great people, and we have a tendency of pulling together to help."
A few cars were also lost in the fire.
Chief Curra said the Red Cross was on scene to help the family. The family was treated on scene for smoke inhalation, but no one needed hospitalization.
The cause of the fire is under investigation.