Firefighters said they got the call around 2:15 a.m. and said when they got to the scene they saw flames rolling out of the top of the roof.
Firefighters broke through a home on Stanley Road in Medway as they tried to put out hot-spots. The home had heavy damage, and the roof crumbled inwards. Smoke was still visible several hours after the call came in.
"Multiple agencies were toned out because of the severeness of the fire," said Aaron Lee, fire chief with the Medway Fire Department.
Officials said three people were in the house at the time of the fire, and one person was injured.
Chief Lee said one person with minor burns was taken to the hospital.
A neighbor who lives directly across the street said her husband woke up to the sound of fire trucks.
"He come in and woke me up, and told me that Ben's house was on fire," said Lillian Stanley.
Stanley said she's lived on the street her whole life, and said a scene like that made her nervous with her home so close to the fire.
"Yeah, I could see the flames from the back. Then by 3:30 they were coming right out of the front of the house, windows and things," said Stanley. "It was coming high, then coming out of the front of the house," she said.
Chief Lee said they had some problems battling the flames because of a lack of water. The fire marshall is investigating the cause.