Crews were called to an old farm house on the Hudson Road before 6 a.m.
Initial reports led first responders to believe a man and woman were still inside the home.
Firefighters later determined both made it out of the home before they arrived.
One was taken to St. Joseph's Hospital and the other was taken to Eastern Maine Medical Center to be treated for injuries.
"We think there's a shoulder injury on the female and she had some cuts and bruises," says Sgt. Scott Richardson of the Maine State Fire Marshal's Office. "And the other one was some smoke [inhalation] and we took him down to have him checked out."
Both are expected to okay.
Crews had the fire mostly knocked down around 8 a.m.
The State Fire Marshal's Office is investigating the cause.
Departments from Corinth, Levant, Bradford, and Charleston helped put out the flames.