Officials were called to the scene around 6 p.m. on Route 1 in Dennysville near the Route 86 intersection.
Justin Wentworth, 42, of Pembrook was driving a Chevrolet pick up when it struck another pick up driven by Nancy Curtis, 36, of Dennysville.
Both drivers were sent to the hospital. Curtis was then taken by LifeFlight to EMMC in Bangor for serious but non-life threatening injuries.
The crash is under investigation.