The call came in around 1 a.m. to a home on Gross Point Road in Orland.
Someone across the river on Verona Island saw the flames and called fire crews.
Orland fire officials say one woman was able to make it out of the home, but had to be taken to Eastern Maine Medical Center for burns.
She was the only person inside, but a dog died in the fire.
"The entire end of the house garage was in flames," says Julia Gray, Assistant Fire Chief with the Orland Fire Department. "You couldn't get anywhere near the house when we first got here."
"Within about an hour we had it relatively under control," she adds. "The challenge was because of the heavy fire, we couldn't really get inside the house, so trying to get in the basement and in the attic has been the real challenge."
The home is a total loss.
Crews from Bucksport, Penobscot and Orrington helped put out the flames and are expected to remain on scene for a few hours to help state fire marshals investigate.