Kobe Bryant scored 26 points and Pau Gasol had 25 for the Lakers, whose road skid is their longest in six years. Dwight Howard was ejected after drawing his second technical foul with 1:18 left in the first half.
Jose Calderon had 22 points and nine assists while Ed Davis had 18 points and eight rebounds for Toronto. Alan Anderson added 14 points and eight assists as the Raptors ended a four-game losing streak against the Lakers.
Bryant made 10 of 32 shots, including 3 of 12 on 3-pointers.