"The San Francisco 49ers reject the comments that were made yesterday, and have addressed the matter with Chris," the team said in a statement. "There is no place for discrimination within our organization at any level. We have and always will proudly support the LGBT community."
Culliver made the comments during a Media Day interview with radio host Artie Lange.
"I don't do the gay guys, man," said Culliver, whose team will square off against the Baltimore Ravens in Super Bowl XLVII on Sunday. "I don't do that. No, we don't got no gay people on the team, they gotta get up out of here if they do.
"Can't be with that sweet stuff. Nah … can't be … in the locker room, man. Nah."
After those inflammatory comments, Lange followed up by asking if any gay players would need to keep their sexuality a secret, to which Culliver answered, "Yeah, come out 10 years later after that."
Culliver has played in every 49ers game this season. He racked up 47 tackles and two interceptions in the regular season and had an interception in the NFC title game victory over the Atlanta Falcons.