The China Garden at the University Mall in Old Town was robbed Friday night, the Thai Kitchen on Park Street in Orono was hit Saturday night, and another Orono business, The Family Dog, was robbed Sunday night.
Orono and Old Town police are working together on the investigation.
They say an undisclosed amount of cash was taken, along with several other items.
Officials say it was the method of the break-ins that led them to believe that they are looking for the same suspects.
"It's unusual for those three break-ins to occur so similarly," Chief Josh Ewing, of the Orono Police Department, says. "We believe there were similar breaks in others towns as well. It's been many years since we've seen this type of repetitive break-ins for businesses in this area."
For one of the owners the string of break-ins on small businesses is what stands out the most - shops that impact the community.
"Customers were in disbelief," Bob Cutler, owner of The Family Dog, says. "They couldn't believe it. But we had people saying that they'd come in this week to support us. I just hope that whoever did it wakes up and realizes they're stealing money from a lot of small businesses that can't always afford to lose that money."
Anyone with information is urged to contact the Orono Police Department at (207) 866-4000. If you'd like to remain anonymous you can visit the department website.