The Somerset County Sheriff's Office reports the raid happened just before 9 a.m. at a home on Main Street.
A search of the home turned up several grams of fentanyl powder, numerous firearms, almost $3,000 in cash and other evidence related to the drug business.
Brian Leavitt, 30, and Ashleigh Richmond, 26, are both charged with aggravated trafficking and possession of a scheduled drug.
Officials said Leavitt may face additional charges once all the seized evidence is tested and weighed.
A Maine drug agent and Pittsfield police also took part in the raid as part of an ongoing effort to crack down on illegal drugs in Somerset County.